Table 5.

Mutations associated with resistance to delamanid in ≥2 isolates reported by ≥2 studies or ≥3 isolates reported by ≥1 study^a

Gene	Mutation	MIC summary	MIC change by mutant/study	Data summary	References (in order of data in column 4 and separated by semicolons)
ddn	W88*	≥32 mg/L for REMA and ≥16 mg/L for MGIT	REMA MIC ≥32 mg/L, MGIT MIC ≥16 mg/L (3 clinical isolates, no parent, REMA ECOFF 0.03 mg/L and 0.06 mg/L for MGIT)	3 clinical isolates	Schena 2016 15
ddn	L107P	≥1 mg/L	REMA MIC ≥32 mg/L and MGIT MIC ≥16 mg/L (1 clinical isolate, no parent, MGIT ECOFF 0.03 mg/L for REMA and 0.06 mg/L for MGIT); 7H11 MIC 1 mg/L (no parent)	2 clinical isolates	Schena 2016;15Fujiwara 201861

REMA, resazurin microtitre assay.

^aLow confidence data are underlined.