Table 6.

Mutations associated with resistance to pretomanid in ≥2 isolates reported by ≥2 studies or ≥3 isolates reported by ≥1 study

Gene	aa change [nt]	MIC summary (relative to parent for available isolates)	MIC change by mutant/study	Data summary	References
fbiC	V720I [G2158A]	≥1–10×	≥10× (1 isolate), ≥1× (0.36 mg/L selection concentration, 3 isolates, parent MIC ≤0.36 mg/L) ≥5× (1.8 mg/L selection concentration, 1 isolate, parent MIC ≤0.36 mg/L)	5 in vitro selected mutants, MIC testing done for only 1 isolate	Haver 201560
fbiC	P372S [C1114T]	≥5×	≥5× (1.8 mg/L selection concentration, 3 isolates parent MIC ≤0.36 mg/L)	3 in vitro selected mutants, MIC testing not performed	Haver 201560
fbiC	frameshift [ins C2549]	≥5×	≥5× (1.8 mg/L selection concentration, 4 isolates, parent MIC ≤0.36 mg/L)	4 in vitro selected mutants, MIC testing not performed	Haver 201560
ddn	S11*	≥10×	≥10× (15 isolates)	15 in vitro selected mutants	Haver 201560
ddn	Y133D	≥5×	≥5× (1.8 mg/L selection concentration, 3 isolates)	3 in vitro selected mutants, MIC testing not performed	Haver 201560