Table 2.
Discrete event simulation input parameters after diagnosis
| Input parameters | Costs, $ |
Utility | Range | Sources | ||
|---|---|---|---|---|---|---|
| First year | Years 2 to 5 | Years ≥6 | ||||
| Local | 23 013 | 9862 | 1972 | 0.82 | (0.82, 0.84) | Plevritis et al., 2006 (16), Naik et al., 2015 (18), Cott Chubiz et al., 2013 (25), Mittmann et al., 2014 (29), and de Oliveira et al., 2016 (33) |
| Regional | 39 942 | 17 118 | 5135 | 0.77 | (0.74, 0.80) | Plevritis et al., 2006 (16), Naik et al., 2017 (19), Cott Chubiz et al., 2013 (25), Mittmann et al., 2014 (29), and de Oliveira et al., 2016 (33) |
| Distant | 51 215 | 21 949 | 21 949 | 0.75 | (0.72, 0.78) | Plevritis et al., 2006 (16), Naik et al., 2015 (18), Cott Chubiz et al., 2013 (25), Mittmann et al., 2014 (29), and de Oliveira et al., 2016 (33) |
| Remission* | N/A | N/A | N/A | 0.84 | (0.76, 1.00) | Assumed |
| Terminal stage† | N/A | N/A | 20 452 | 0.75 | (0.59, 0.78) | Plevritis et al., 2006 (16), Mittmann et al., 2014 (29), and Grann et al., 2002 (32) |
| Death | N/A | N/A | N/A | 0 | Not varied | Assumed |
*
Assumed return to baseline high risk. All costs fall to zero after 10 years. N/A = not applicable.
†
Equivalent cost of terminal stage regardless of phase determined by expert opinion. Death cost is the average hourly wage of employees in 2015 multiplied by a 40-hour work week and 52 weeks of work and mortality costs in first year.