Table 5.
Commercially available MNs.
| Type of MNs | Product Name | Company Name | Description of the Product | Use |
|---|---|---|---|---|
| Solid | Dermapen | Dermaroller GmbH | An array of 12 needles loaded on an electric motor unit fitted with a spring that punches skin (412–700 cycle/min) | Treatment of isolated scars, skin lesions and wrinkles, appropriate for smaller areas of the skin |
| Dermaroller | Whitelotusbeauty | Contains 192 titanium needles (0.5 mm long) in cylindrical assembly | Cosmetic application and skin care with cream and serum, appropriate for larger areas of the skin | |
| Dermastamp | Whitelotusbeauty | An array of 40 needles loaded on an electric motor unit with controlled motion back and forth like stamp | Collagen induction therapy for skin scars, age spots, varicella scars and wrinkles, appropriate for smaller areas of the skin | |
| DermaFrac | Dermafrac.co | Very small stainless steel MNs roller equipped with electric power source and instrument for serum infusion, also contains light emitting devices | Wrinkles, skin ageing, hyperpigmentation, acne, uneven skin tone | |
| Onvax | Becton Dickinson | An array of silicon or plastic micro-projections on a hand-held applicator | Vaccine delivery | |
| LiteClear | Nanomed skincare | Silicon MNs pen for skin pretreatment | Treatment of acne and skin blemishes | |
| h-patch | Valeritas | Small adhesive MNs, hydrolytically regulated | Basal and bolus delivery of insulin | |
| Beauty Mouse | Dermaroller GmbH | Three rollers of 50 mm width and a total of 480 MNs, creating fine microchannels for enhanced penetration | Increasing the skin’s sensitivity towards anti-cellulite creams | |
| NanoCare | NanoPass Inc. | A small hand-held device for the rejuvenation of skin and to boost the cosmetic effect of topical applications | Cosmetic | |
| Adminstamp | AdminMed | MNs array attached to the applicator with six stainless steel screws (1400 µm-long MNs on 1 cm2 circular array), compatible with all sterilization methods | Transdermal drug delivery through the skin with excellent skin sensation and cosmetics | |
| Coated | MacroFLUX™ | Zosano pharma | PTH-coated titanium MN patch | Osteoporosis |
| Nanopatch | Vaxxas | Silicon patch (1 cm2) made up thousands of coated micro-projections | Polio vaccine | |
| Hollow | 3M MTS | 3M Corp | MN patch containing 351 needles/cm2 (650 µm length) | Skin treatment before dermatological application |
| FLUARIX | GlaxoSmithKline Biologicals | Three MNs (600 µm length) attached to a syringe | Influenza vaccine delivery | |
| Micronjet | Nanopass | Four silicon MNs (450µm length) attached to the tip of a plastic adapter | Intradermal vaccine delivery | |
| Fluzone | Sanofi Pasteur Inc Becton Dickinson |
A hand syringe gun unit that injects 1.5 mL vaccine solution by a micro-injector in intradermal site by a 1.5 mm MN tip | Influenza vaccine | |
| Soluvia | Sanofi-Aventis Becton Dickinson |
MNs (length 1.5 mm) for intradermal delivery | Influenza vaccine | |
| Microinfusor | Becton Dickinson | An automated hands-free system consists of an electrical pump connected to a hollow MN patch (capacity 0.2–15 mL) | Influenza vaccine, insulin, and highly viscose biotech drug | |
| Nanoject | Debiotech | Based on MEMS technology, hollow MN patch (length 300 to 1000 µm), featuring side holes which prevent sticking in the MN channels during skin penetration | Intradermal drug delivery and injection of diagnostic fluid | |
| Micro-Trans | Valeritas Inc. | Hollow MNs constructed with metal or biodegradable polymers | Intradermal drug delivery | |
| Intanza/IDflu | Sanofi-Aventis Becton Dickinson |
MNs (length 1.5 mm) combined with a needle shielding system and a 0.1 mL injection volume | Influenza vaccine | |
| AdminPen | AdminMed | Forty-three needles (length 1100 µm) on 1 cm2 circular microneedle array, stainless steel liquid injector device attached to a standard syringe | Liquid formulations (vaccines, drug) | |
| Microinject | Nanopass | Four hollow silicon MNs (length 250 µm), fitted with a syringe for intradermal injection | Influenza vaccine | |
| DebioJect | Debiotech | One or several hollow silicon MNs with a length ranging from 350 to 900 µm and a side protected delivery holes, injections up to 0.5 mL in a few seconds | Vaccine delivery | |
| Dissolving | Drugmat® | Theraject Inc. | Sumatriptan-loaded dMN patch made from a sugar polysaccharide | Migraine |
| Vaxmat® | Theraject Inc. | Sumatriptan-load dMNs | Migraine | |
| MicroCor | Coriumintl | PTH-loaded dissolvable peptide MN patch | Osteoporosis | |
| MicroHyala | CosMed | MN patch made of biocompatible hyaluronic acid | Wrinkle treatment, influenza vaccine |
PTH: parathyroid hormone, microstructured transdermal system technology.