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Schematic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein. (A) The primary structure of S with its domains: signal peptide (SP), receptor binding domain (RBS), fusion peptide (FP), heptad repeat (HR), transmembrane (TM), and cytoplasmic tail (CT). (B) Side and top view of the three-dimensional structure of the trimeric spike protein in the perfusion confirmation. Image created from the structure with Protein Data Bank (PDB) identifier VXX6.
