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. 2021 Jan 6;10(1):104. doi: 10.3390/foods10010104

Figure 10.

Figure 10

The upstream regulator network for PPARGC1α for WB myopathy vs. control breast muscle in commercial broilers (A) and high vs. low FE PedM (B) proteomic datasets [11]. The predicted inhibition of PGC1α in WB myopathy was associated with the predicted inhibition of Complex I of the mitochondrial electron transport chain in WB myopathy (C), whereas the predicted activation of PGC1α in high FE was associated with predicted activations of Complex I, III and IV of the mitochondrial electron transport chain (D). The regulatory network for PPARGC1A showing the downstream target molecules involved in the predictions of inhibition of vasculogenesis and oxidation of fatty acid and activation of reactive oxygen species (ROS) production and quantity of adipose tissue (E). Protein abbreviations in (A,E) are defined and differential expression of proteins are provided in Supplementary Table S1. Protein abbreviations for (D) are as follows: COX4I1 (cytochrome oxidase subunit IV isoform 1), CTSC (cathepsin C), GPX1 (glutathione peroxidase 1), NDUFB5 (NADH dehydrogenase (ubiquinone) Complex I assembly factor 5), NDUFB8 (NADH dehydrogenase (ubiquinone) beta subcomplex, 8), OMM (Outer Mitochondrial Membrane), IMM (Inner Mitochondrial Membrane).