Figure 11.

The upstream regulatory networks for ARNT (A) and AHR (B). The predicted inhibition of ARNT was based on the downstream expression of proteins that are shown and was associated with predicted inhibition of apoptosis, vasculogenesis and glycolysis and prediction of activation of fibrosis. Conversely, the expression of downstream target molecules of involved in predicting inhibition of AHR were associated with predictions of enhanced angiogenesis and necrosis. The discrepancy in the prediction of active necrosis in the AHR and prediction of inhibition of necrosis in the entire dataset shown in Table 2 is based on the smaller subset of expression data for AHR compared to the overall dataset. Protein abbreviations are defined and differential expression of proteins are provided in Supplementary Table S1.