Figure 12.

ESRRGamma (ESRRG or ESSRγ) was predicted to be inhibited in WB myopathy based on the expression of downstream molecules shown in this regulatory network. The regulatory network resulted in the prediction of the inhibition of vasculogenesis and activation of necroptosis. As in Figure 9, discrepancies in the predictions of these functions and those in Table 2 are due to a smaller subset of proteins in the ERRG upstream regulatory network, compared to the larger set of proteins listed for functions in Table 2. Protein abbreviations are defined and differential expression of proteins are provided in Supplementary Table S1.