Table 2.
Functions predicted to be activated (orange) or inhibited (blue) in wooden breast (WB) myopathy compared to normal muscle based on differentially expressed (DE) target molecules in commercial broilers.
| Functions | Activation z-Score | p-Value of Overlap | Differentially Expressed Proteins 1 |
|---|---|---|---|
| Development of vasculature | 2.45 | 1.21 × 10−3 | ACP1, ANXA2, C3, CALR, CAPNS1, CDH13, CRYAB, CTSB, FGA, FLNA, HSPA5, IGHM, LDHA, PGK1, PKM, PPIA, RHOA, VIM, YWHAZ |
| Vasculogenesis | 2.43 | 4.46 × 10−4 | ACP1, ANXA2, C3, CALR, CAPNS1, CDH13, CRYAB, CTSB, FLNA, HSPA5, LDHA, PKM, PPIA, RHOA, VIM, YWHAZ |
| angiogenesis | 2.30 | 1.67 ×10−3 | ACP1, ANXA2, C3, CALR, CAPNS1, CDH13, CRYAB, CTSB, FLNA, HSPA5, LDHA, PGK1, PKM, PPIA, RHOA, VIM, YWHAZ |
| Necrosis | −3.33 | 2.68 × 10−11 | ACP1, ANXA2, C3, CALR, CAPNS1, CBR1, CRYAB, CS, CTSB, DDX3X, DYNC1H1, EEF1A1, EIF3L, FDPS, FGA, FLNA, GAPDH, GLO1, HINT1, HK1, HNRNPH1, HSP90AA1, HSP90B1, HSPA5, IGHM,KLHL40, LDHA, P4HB, PARK7, PDCD6IP, PDIA3, PEBP1, PKM, POSTN, PPIA, PRDX6, PSMC2, RACK1, RAN, RHOA, RPL11, RPL6, RPLP0, RPS11, RPS14, RPS24, RPS3, Rps3a1, RPS6, RPS7, TAGLN2, UBE2V2, VIM, YWHAE, YWHAZ |
| Cell death | −3.05 | 2.01 × 10−9 | ACP1, AK1, ALDOC, ANXA2, C3, CALR, CAPNS1, CBR1, CRYAB, CS, CTSB, DDX3X, DES, DYNC1H1, EEF1A1, EIF3L, FDPS, FGA, FLNA, GAPDH, GLO1, HINT1, HK1, HNRNPH1, HSP90AA1, HSP90B1, HSPA2, HSPA5, IGHM, KLHL40, LDHA, P4HB, PARK7, PDCD6IP, PDIA3, PEBP1, PKM, POSTN, PPIA, PRDX6, PSMC2, RAB1A, RACK1, RAN, RHOA, RPL11, RPL6, RPLP0, RPS11, RPS14, RPS24, RPS3, Rps3a1, RPS6, RPS7, TAGLN2, UBE2V2, VIM, YWHAE, YWHAZ |
| Apoptosis | −1.98 | 4.61 × 10−6 | ALDOC, ANXA2, C3, CALR, CAPNS1, CRYAB, CS, CTSB, DDX3X, DES, DYNC1H1, EEF1A1, FLNA, GAPDH, GLO1, HINT1, HK1, HNRNPH1, HSP90AA1, HSP90B1, HSPA2, HSPA5, IGHM, KLHL40, LDHA, P4HB, PARK7, PDCD6IP, PDIA3, PEBP1, PKM, PPIA, PRDX6, RACK1, RHOA, RPLP0, RPS24, RPS3, RPS6, TAGLN2, UBE2V2, VIM, YWHAE, YWHAZ |
1 Target proteins in plain red type were up-regulated (p < 0.05, >1.3-fold difference) in WB myopathy compared to normal tissue. Target molecules in bold green and underlined type were down-regulated (p < 0.05, <−1.3-fold difference) in WB myopathy compared to normal tissue.