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. 2021 Jan 7;11(1):69. doi: 10.3390/biom11010069

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cholesteryl ester transfer protein (CETP) expression impairs endothelium-dependent relaxation. Endothelium-dependent relaxation in response to acetylcholine (Ach, panel (A)) or to NO donor sodium nitroprusside (SNP, panel (B)) in isolated aortic rings pre-contracted with phenylephrine. Acetylcholine-induced vessel-relaxation is dependent on nitric oxide synthase (eNOS) activity, since it is abolished in the presence of N(ω)-nitro-L-arginine methyl ester (L-NAME, panel (C)) in aortas of both CETP-transgenic (CETP) and non-transgenic mice (Ntg). Data are mean ± SEM (n = 10 per group). * p < 0.05 for pD2 and Emax by two-way ANOVA.