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Penetration profiles of procaine HCl in porcine skin after the skin incubation time of 14 h (A), 20 h (B) and 24 h (C) with the measurements of the off-line device. Two procaine-HCl containing formulations were compared: formulation with enhancer (red triangles) and without enhancer (green circles). Mean ± SD (n ≥ 9).
