Figure 2.

Mechanism of action of ADC(s). ADC(s) can exert their cytotoxic properties directly or indirectly using the immune system. Once the antibody binds the target antigen on the cell surface, it is internalized and the payload is released into the cytoplasm, interfering with the cellular functions (DNA damage, microtubules inhibition), inducing apoptosis. Otherwise, some ADC(s) can activate immune effector cells by Fc-Fc receptor interaction, inducing ADCC or ADCP. ADCC: antibody dependent cellular cytoxocity. ADCP: antibody dependent cellular phagocytosis.