. 2021 Jan 7;13(2):180. doi: 10.3390/cancers13020180

Table 1.

Summary of studies about the role of HIF in cisplatin-induced AKI.

Number	Model	Strategies for HIF Regulation	Involved HIF Isoforms	Is HIF Activated or Inhibited	Effects	Underlying Mechanisms	Reference
1	Rats	cobalt	HIF-1 and HIF-2,	activated	attenuate AKI	apoptosis reduction via regulating mitochondrial pathways	[16]
	IRPTC,	cobalt	HIF-1	activated	improve IRPTC survival	apoptosis reduction via regulating mitochondrial pathways	[16]
2	Rats;	Carbon monoxide preconditioning	HIF-1	activated	attenuated AKI	apoptosis reduction	[17]
	HCK-8 cells	Carbon monoxide preconditioning	HIF-1	activated	reduced apoptosis, increased proliferation	apoptosis reduction	[17]
3	Mice;	PHD inhibitor FG-4592	HIF-1	activated	attenuated AKI	apoptosis reduction, ameliorated inflammation	[18]
	HK-2 cells	PHD inhibitor FG-4592	HIF-1	activated	reduced apoptosis	apoptosis reduction, ameliorated inflammation	[18]
4	Rats	deferiprone	HIF-1	activated	attenuated AKI	reduce apoptosis with increased Mcl1 and survivin expression	[19]
5	Mice	EC-specific Phd2+/− mice	HIF-1, HIF-2	activated	attenuated AKI	induced antioxidative response	[149]
6	HK-2 cells	lentivirus-mediated HIF-1α-transfected hASCs	HIF-1	activated	reduced apoptosis and improved cellular morphology	reduced apoptosis	[150]
7	Mice	lentivirus-mediated HIF-1α-transfected hASCs	HIF-1	activated	attenuated AKI	reduced apoptosis, ameliorated inflammation	[151]

IRPTC, immortalized rat proximal tubular cells; HCK-8, human renal proximal tubular cell line; HK-2, human proximal tubule epithelial cells; Mcl1, Myeloid cell leukemia-1; EC, endothelial cell; hASCs, Human adipose-derived stem cells.