Figure 3.

The effect of microenvironment and organospecificity on the angiogenic potential of Endothelial cells (ECs). Morphology of tubes formed in vitro by healthy and cancer-derived EC cells after 5 h in normoxia or hypoxia. Low pO₂ reduces the pro-angiogenic response in ECs derived from tumor site when compared to normoxia. In the case of healthy tissue-derived ECs, hypoxia does not significantly influence tube formation. (A)—healthy ECs, normoxia; (B)—healthy ECs, hypoxia; (C)—cancer-derived ECs, normoxia; (D)—cancer-derived ECs, hypoxia; magnification 5×.