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. 2021 Jan 7;22(2):532. doi: 10.3390/ijms22020532

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overview of PPIs-based drug repurposing. SARS-CoV-2 interactomes are generated by affinity purification Mass Spectrometry (AP-MS) or by Proximity-Dependent Biotin Labeling (BioID). Interactions between SARS-CoV-2 viral baits proteins and host proteins targetable by already approved drugs are selected. Next, druggable host targets are analysed by biochemical and cell-based assays for antiviral activity. Selected lead compounds with in vitro anti-viral efficacy are then tested for in vivo efficacy on COVID-19 patients.