Table 2.
Average fraction of cell populations.
| Pre-Challenge (% of Total Cell Population) | Post-Challenge (% of Total Cell Population) | |
|---|---|---|
| B cells naive | 42.07 ± 0.02 | 39.89 ± 0.01 |
| B cells memory | 0.00 ± 0.00 | 0.62 ± 0.01 |
| Plasma cells | 0.38 ± 0.00 | 0.00 ± 0.00 * |
| T cells CD8 | 2.37 ± 0.00 | 0.46 ± 0.00 ** |
| T cells CD4 naive | 5.52 ± 0.02 | 6.95 ± 0.02 |
| T cells CD4 memory resting | 1.34 ± 0.01 | 1.04 ± 0.01 |
| T cells CD4 memory activated | 5.55 ± 0.01 | 3.28 ± 0.01 |
| T cells follicular helper | 17.75 ± 0.02 | 16.69 ± 0.01 |
| T cells regulatory (Tregs) | 0.88 ± 0.00 | 1.05 ± 0.01 |
| T cells gamma delta | 1.11 ± 0.00 | 4.00 ± 0.00 ** |
| Natural killer cells resting | 2.32 ± 0.01 | 1.32 ± 0.01 |
| Natural killer cells activated | 0.18 ± 0.00 | 0.51 ± 0.00 |
| Monocytes | 4.38 ± 0.01 | 4.71 ± 0.01 |
| Macrophages M0 | 1.49 ± 0.00 | 0.00 ± 0.00 * |
| Macrophages M1 | 0.00 ± 0.00 | 2.14 ± 0.01 * |
| Macrophages M2 | 2.39 ± 0.00 | 3.18 ± 0.00 |
| Dendritic cells resting | 0.00 ± 0.00 | 0.66 ± 0.00 |
| Dendritic cells activated | 4.98 ± 0.00 | 5.84 ± 0.01 |
| Mast cells resting | 0.00 ± 0.00 | 0.64 ± 0.01 |
| Mast cells activated | 2.89 ± 0.01 | 1.54 ± 0.01 |
| Eosinophils | 4.22 ± 0.01 | 4.92 ± 0.01 |
| Neutrophils | 0.15 ± 0.00 | 0.55 ± 0.00 |
The average fraction of cell population fractions for each sample was estimated using CIBERSORTx [28] and the reference gene signature “LM22” included with the software, which is based off of the transcriptome of human PBMC samples with pre-determined cell populations. Wilcoxon’s signed-rank test was performed. * indicates p ≤ 0.1 and ** indicates p ≤ 0.05.