Table 2.
Initial dose finding trials of SBRT for HCC.
| Study | Year | Sample Size | Dose Schedule | Median Follow-Up (Months) | OS Rate | LC | Toxicity |
|---|---|---|---|---|---|---|---|
| Méndez Romero [15] | 2006 | 8 (HCC) | 37.5/3 * 30/3 25/5 |
12.9 | 75% 1 year 40% 2 years |
75% | 2 RILD 1 Grade 5 |
| Tse [16] | 2008 | 31 (HCC) | 36/6 median |
17.6 | 48% 1 year | 65% | No grade ≥ 4 |
| Andolino and Cárdenes [17] | 2011 | 60 | 48/3 40/5 |
27 | 67% 2 years | 90% | No grade ≥ 3 |
| Bujold [18] | 2013 | 102 | 36/6 median |
31.4 | 55% 1 year 34% 2 years |
87% | 7 Grade 5 |
* 37.5 Gy/3 fractions; OS: Overall Survival; LC: Local Control; RILD: Radiation-Induced Liver Disease.