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. 2021 Jan 7;10(1):67. doi: 10.3390/antiox10010067

Figure 2.

Figure 2

The effect of Resvega (R 0.1–25 μM; DMSO 0.5% v/v) on the cell viability in IL-1α-primed ARPE-19 cells in conjunction with proteasome (MG; 5 μM) and autophagy (bafilomycin A1 (BafA); 50 nM) inhibitor treatments. Rupturing of cell membrane is indicated by the LDH assay (A) and metabolic activity using the MTT assay (B). Results are compared to the untreated control group, which was set to be 1 (A) or 100% (B). Resvega was diluted by DMSO which served as the diluent control to Resvega. Untreated cells served as controls for interleukin (IL)-1α-primed cells, and IL-1α for IL-1α-primed cells with inflammasome activators, MG-132 and BafA. Data are combined from 3 independent experiments containing 4 parallel samples per group in each experiment. Results are shown as mean ± standard error of mean (SEM) and analyzed using the Mann–Whitney U-test. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns—not significant.