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. 2021 Jan 7;10(1):67. doi: 10.3390/antiox10010067

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of Resvega (R10 μM; DMSO 0.5% v/v) on the secretion of IL-1β (A) and NLRP3 (B) upon MG-132 (MG; 5 μM) and bafilomycin A1 (BafA; 50 nM) exposure in IL-1α-primed ARPE-19 cells. Resvega was diluted by DMSO which served as the diluent control to Resvega. Untreated cells served as controls for IL-1α-primed cells, and IL-1α for IL-1α-primed cells with inflammasome activators MG-132 and BafA. Data are combined from 3 independent experiments containing 4 (A) or 3 (B) parallel samples per group in each experiment. Results are shown as mean ± SEM and analyzed using the Mann–Whitney U-test. ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns—not significant.