Table 2.
Clinical characteristics.
| Survivors n = 18 | Non-survivors n = 16 | P-value | |
|---|---|---|---|
| Total hospital stay, days (IQR) | 19 (4–49) | 10 (0–37) | 0.02 |
| Baseline SOFA score, (IQR) | 3 (2–5) | 4 (3–6) | 0.16 |
| Max QTc on ECG, msec (IQR) | 452 (433–493) | 468 (434–494) | 0.8 |
| Laboratory findings: | |||
| Leukocytes, x109/L (IQR) [3.9 - 10.6] | 11.1 (9.5–12.8) | 11.5 (8–17.7) | 0.52 |
| Hemoglobin, g/L (IQR) [137–175] | 129 (112–142) | 114 (102–133) | 0.18 |
| Platelets, x109/L (IQR) [150 - 400] | 187 (148–224) | 151 (133–194) | 0,31 |
| Lymphocytes, x109/L (IQR) [0.7 - 5.0] | 0.95 (0.66–1.23) | 0.62 (0.54–0.91) | 0.01 |
| *Troponine I, ng/L [<15.6] | 54 (2.7–447.6) | 51.5 (10–2625.2) | 0.86 |
| Creatinine, mmol/L (IQR) [0.05–0.09] | 0.12 (0.07–0.18) | 0.13 (0.09–0.17) | 0.97 |
| AST, μmol/s•L (IQR) [0.17 - 0.7] | 0.51 (0.34–0.78) | 0.64 (0.53–0.81) | 0.68 |
| ALT, μmol/s•L (IQR) [0.0 - 0.68] | 0.52 (0.26–0.86) | 0.38 (0.23–0.51) | 0.24 |
| C-reactive protein, nmol/L (IQR) [0.0 - 46.7] | 840 (477–1682) | 1417 (766–2236) | 0.27 |
| *LDH, μmol/s•L (IQR) [<4.1] | 4.5 (3.1–4.9) | 7 (5.3–9.3) | 0.00 |
| *D-Dimer, mg/L (IQR) [<0.5] | 1.63 (0.63–5.6) | 2.72 (1.6–5.6) | 0.46 |
| *Ferritin, nmol/L (IQR) [0.01 - 0.45] | 1.0 (0.4–2.36) | 1.6 (0.7–5.3) | 0.23 |
| PaO2:FiO2 (IQR) | 241 (222–268) | 171 (83–218) | 0.003 |
| In-hospital treatment | |||
| Hydroxychloroquine (%) | 15 (83.3) | 13 (81.3) | 1 |
| Corticosteroids (%) | 9 (50.0) | 7 (43.8) | 0.71 |
| Canakinumab (%) | 0 (0.0) | 1 (6.3) | 0.47 |
| Antibiotic therapy (%) | 17 (94.4) | 15 (93.8) | 1 |
| Antiviral therapy (%) | 7 (38.9) | 10 (62.5) | 0.17 |
| LMWH (%) | 18 (100.0) | 11 (68.8) | 0.02 |
| Beta-blockers (%) | 10 (55.6) | 2 (12.5) | 0.01 |
| In-hospital complications | |||
| Acute kidney failure (%) | 6 (33.3) | 5 (31.3) | 0.89 |
| Acute heart failure (%) | 2 (11.1) | 0 (0.0) | 0.49 |
| Atrial fibrillation (%) | 1 (5.6) | 1 (6.3) | 1 |
| Deep vein thrombosis (%) | 1 (5.6) | 1 (6.3) | 1 |
| Pulmonary embolism (%) | 1 (5.6) | 0 (0.0) | 1 |
| Bleeding (%) | 1 (5.6) | 0 (0.0) | 1 |
| Sepsis (%) | 1 (5.6) | 2 (12.5) | 0.59 |
| Acute coronary syndrome (%) | 0 (0.0) | 2 (12.5) | 0.21 |
⁎
Laboratory findings with missing data, LMWH (Low molecular weight heparin), SOFA (Sequential Organ Failure Assessment), Max (maximum), QTc (corrected QT interval), ECG (Electrocardiogram), [normal laboratory values].