Table 1.

Agents active against RAS that modulate ACE-2 and their hypothetical use in the various stages of SARS-CoV-2 infection^a

Phase of infection	ACE-2 (-)	ACE-2 (+)
1	DRis
2		ACEis
3		ARBs

^aDuring the prevention and Phase 1 stages of viral infection, it might be useful to decrease ACE-2 concentrations with DRis, whereas, during the more severe stages, an increase in ACE-2 with ACEis and ARBs might have a protective role.