Fig. 2.

Results of network pharmacology. (A) Compound-target gene interactions for RDNI. The purple nodes represent the compounds, the yellow nodes represent the targets co-expressed with ACE2, the red nodes represent the targets that are related to fever, and the green nodes represent the other targets. All the nodes were sorted by degree. The color round represents the targets of the cytokine storm. The radius of the point is proportional to the degree. More details of the network can be found in Supplementary file 2. (B) PPI network. All the nodes represent the targets of RDNI. The edges represent the interaction between targets. The higher the degree, the darker the color. More information on the network was list in Supplementary file 3. (C)Bubble charts of KEGG enrichment analysis. The dot size is proportional to the number of genes, and the color of the dot represents the p-value of each enrichment pathway. (D) Bubble charts of GO enrichment analysis. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)