Table 2.
Predicted toxicity properties of selected Nsp15 endoribonuclease modulators – inhibitors.
| Toxicity properties | N1 | N2 | N3 | N4 | N5 |
|---|---|---|---|---|---|
| AMES toxicity | No | No | No | No | No |
| Max. tolerated dose (human) | −0.63 | −0.19 | −0.86 | 0.65 | 0.30 |
| hERG I/hERG II inhibitor | No/No | No/No | No/No | No/No | No/No |
| Oral Rat Acute Toxicity (LD50) | 2.33 | 1.47 | 2.21 | 1.50 | 2.07 |
| Oral Rat Chronic Toxicity (LOAEL) | 1.04 | 0.62 | 0.89 | 0.96 | 1.02 |
| Hepatotoxicity | No | No | No | No | No |
| Skin Sensitization | No | No | No | No | No |
| T.Pyriformis toxicity | 0.41 | 0.27 | 0.44 | 0.09 | 0.27 |
| Minnow toxicity | 2.53 | 2.00 | 2.62 | 3.06 | 3.10 |