Table 3.

Bioactivity and efficiency parameters of proposed Nsp15 endoribonuclease modulators.

Molecule	1BE	2LE	3LE_Scale	4FQ	5LELP
N1	−11.539	0.425	0.368	1.154	5.435
N2	−10.639	0.378	0.356	1.061	5.820
N3	−10.507	0.362	0.346	1.046	7.928
N4	−10.347	0.572	0.482	1.186	2.744
N5	−10.361	0.443	0.415	1.067	2.234

¹Binding energy.

²Ligand efficiency.

³Ligand efficiency scale.

⁴Fit quality.

⁵Ligand-efficiency-dependent-lipophilicity.