Table 3.
n | Asthma, % | ORModel1a | 95 % CI | ORModel2b | 95 % CI | ORModel3c | 95 % CI | |
---|---|---|---|---|---|---|---|---|
Allergens—fathers | ||||||||
Asthma 0–3 years | ||||||||
Unexposed | 1216 | 4 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception onlyd | 76 | <7 | – | - | – | |||
Exposed both pre- and post-conception | 235 | 3.8 | 0.93 | (0.43; 2.01) | 0.77 | (0.34; 1.78) | 0.88 | 0.39; 1.99 |
Asthma 4–15 years | ||||||||
Unexposed | 1216 | 11.1 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception only | 76 | 6.6 | 0.60 | (0.21; 1.78) | 0.59 | (0.20; 1.76) | 0.61 | 0.21; 1.81 |
Exposed both pre- and post-conception | 235 | 8.9 | 0.73 | (0.43; 1.24) | 0.74 | (0.44; 1.26) | 0.79 | 0.46; 1.36 |
Allergens—mothers | ||||||||
Asthma 0-3 years | ||||||||
Unexposed | 1445 | 3.0 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception onlyd | 118 | <5 | – | - | – | |||
Exposed both pre- and post-conception | 523 | 5.4 | 1.99 | (1.20; 3.30) | 1.70 | (1.02; 2.84) | 1.85 | 1.08; 3.15 |
Asthma 4–15 years | ||||||||
Unexposed | 1445 | 10.0 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception only | 118 | 16.1 | 1.55 | (0.89; 2.69) | 1.21 | (0.69; 2.14) | 1.07 | 0.60; 1.90 |
Exposed both pre- and post-conception | 523 | 10.9 | 1.07 | (0.76; 1.49) | 0.99 | (0.70; 1.40) | 0.98 | 0.69; 1.40 |
Chemicals—fathers | ||||||||
Asthma 0–3 years | ||||||||
Unexposed | 1216 | 4.4 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception only | 116 | 6.9 | 1.90 | (0.85; 4.26) | 1.37 | (0.57; 3.28) | 1.35 | 0.54; 3.36 |
Exposed both pre- and post-conception | 300 | 3.7 | 0.94 | (0.46; 1.89) | 0.77 | (0.35; 1.68) | 0.65 | 0.29; 1.47 |
Asthma 4–15 years | ||||||||
Unexposed | 1216 | 11.1 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception only | 116 | 8.6 | 0.81 | (0.41; 1.61) | 0.80 | (0.41; 1.55) | 0.75 | 0.37; 1.52 |
Exposed both pre- and post-conception | 300 | 10.3 | 0.87 | (0.55; 1.37) | 0.86 | (0.55; 1.37) | 0.92 | 0.58; 1.47 |
Chemicals—mothers | ||||||||
Asthma 0–3 years | ||||||||
Unexposed | 1445 | 3.0 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception onlyd | 112 | <5 | – | - | – | |||
Exposed both pre- and post-conception | 520 | 5.2 | 1.87 | (1.12; 3.13) | 1.65 | (0.98; 2.77) | 1.82 | 1.06; 3.12 |
Asthma 4–15 years | ||||||||
Unexposed | 1445 | 10.0 | 1.00 | 1.00 | 1.00 | |||
Exposed pre-conception only | 112 | 16.1 | 1.62 | (0.93; 2.84) | 1.34 | (0.76; 2.36) | 1.18 | 0.67; 2.09 |
Exposed both pre- and post-conception | 520 | 11.2 | 1.09 | (0.78; 1.52) | 1.03 | (0.73; 1.45) | 1.03 | 0.72; 1.46 |
ORModel1 cluster by family, adjusted for study center.
ORModel2 cluster by family, adjusted for study center, and parent's characteristic (age, asthma before the age of 10 years, asthma after the age of 10 years, place of upbringing, and smoking) as well as grandmother and grandfathers educational level.
ORModel3 cluster by family, same adjustment as ORModel2 + parent's educational level.
The category was included in the model, but due to very few exposed individuals, the result is not presented. Due to data security, i.e. the European Data Protection Regulation, we are not allowed to show results based on microdata (<5 persons). Data are available on request for authorized research units.