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. 2020 Jul 14;49(6):1856–1869. doi: 10.1093/ije/dyaa085

Table 3.

Multivariable logistic regression analyses clustering by family of paternal or maternal occupational exposure in relation to asthma in offspring; sensitivity analyses of age at asthma onset (0–3 years and 4–15 years)

n Asthma, % ORModel1a 95 % CI ORModel2b 95 % CI ORModel3c 95 % CI
Allergens—fathers
Asthma 0–3 years
 Unexposed 1216 4 1.00 1.00 1.00
 Exposed pre-conception onlyd 76 <7 -
 Exposed both pre- and post-conception 235 3.8 0.93 (0.43; 2.01) 0.77 (0.34; 1.78) 0.88 0.39; 1.99
Asthma 4–15 years
 Unexposed 1216 11.1 1.00 1.00 1.00
 Exposed pre-conception only 76 6.6 0.60 (0.21; 1.78) 0.59 (0.20; 1.76) 0.61 0.21; 1.81
 Exposed both pre- and post-conception 235 8.9 0.73 (0.43; 1.24) 0.74 (0.44; 1.26) 0.79 0.46; 1.36
Allergens—mothers
Asthma 0-3 years
 Unexposed 1445 3.0 1.00 1.00 1.00
 Exposed pre-conception onlyd 118 <5 -
 Exposed both pre- and post-conception 523 5.4 1.99 (1.20; 3.30) 1.70 (1.02; 2.84) 1.85 1.08; 3.15
Asthma 4–15 years
 Unexposed 1445 10.0 1.00 1.00 1.00
 Exposed pre-conception only 118 16.1 1.55 (0.89; 2.69) 1.21 (0.69; 2.14) 1.07 0.60; 1.90
 Exposed both pre- and post-conception 523 10.9 1.07 (0.76; 1.49) 0.99 (0.70; 1.40) 0.98 0.69; 1.40
Chemicals—fathers
Asthma 0–3 years
 Unexposed 1216 4.4 1.00 1.00 1.00
 Exposed pre-conception only 116 6.9 1.90 (0.85; 4.26) 1.37 (0.57; 3.28) 1.35 0.54; 3.36
 Exposed both pre- and post-conception 300 3.7 0.94 (0.46; 1.89) 0.77 (0.35; 1.68) 0.65 0.29; 1.47
Asthma 4–15 years
 Unexposed 1216 11.1 1.00 1.00 1.00
 Exposed pre-conception only 116 8.6 0.81 (0.41; 1.61) 0.80 (0.41; 1.55) 0.75 0.37; 1.52
 Exposed both pre- and post-conception 300 10.3 0.87 (0.55; 1.37) 0.86 (0.55; 1.37) 0.92 0.58; 1.47
Chemicals—mothers
Asthma 0–3 years
 Unexposed 1445 3.0 1.00 1.00 1.00
 Exposed pre-conception onlyd 112 <5 -
 Exposed both pre- and post-conception 520 5.2 1.87 (1.12; 3.13) 1.65 (0.98; 2.77) 1.82 1.06; 3.12
Asthma 4–15 years
 Unexposed 1445 10.0 1.00 1.00 1.00
 Exposed pre-conception only 112 16.1 1.62 (0.93; 2.84) 1.34 (0.76; 2.36) 1.18 0.67; 2.09
 Exposed both pre- and post-conception 520 11.2 1.09 (0.78; 1.52) 1.03 (0.73; 1.45) 1.03 0.72; 1.46
a

ORModel1 cluster by family, adjusted for study center.

b

ORModel2 cluster by family, adjusted for study center, and parent's characteristic (age, asthma before the age of 10 years, asthma after the age of 10 years, place of upbringing, and smoking) as well as grandmother and grandfathers educational level.

c

ORModel3 cluster by family, same adjustment as ORModel2 + parent's educational level.

d

The category was included in the model, but due to very few exposed individuals, the result is not presented. Due to data security, i.e. the European Data Protection Regulation, we are not allowed to show results based on microdata (<5 persons). Data are available on request for authorized research units.