Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 21;33(3):479–498. doi: 10.1016/j.cmet.2021.01.016

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Factors modifying viral entry, replication, and clinical secerity

Depiction of cell surface receptors and co-factors facilitating SARS-CoV-2 entry, the importance of cholesterol metabolism (top panel), and cellular, immune, and pathophysiological abnormalities predisposing people with obesity and diabetes to more severe COVID-19 outcomes (bottom panel). ACE2, angiotensin-converting enzyme 2; HMGB1, high-mobility group box 1 protein; NPR1, neuropilin 1; SR-B1, scavenger receptor class B type 1; TMPRSS2, transmembrane serine protease 2; TMEM41B, transmembrane protein 41B.