Table 2.

Estimation of the initial Reproductive number by three different methods.

Method	Point estimate; ${\mathit{R}}_0$ [95% CI
Maximum Likelihood	2.02 [1.84–2.20]
Maximum Likelihood with missing value bias corrected	1.97 [1.80–2.15]
Exponential Growth	2.11 [2.00–2.24]
Time dependent	2.52 [1.87–3.49]

Note: For the TD method, daily estimates were averaged over the first 38 days and confidence interval was obtained using 1000 bootstrap simulations. The Bias corrected Maximum Likelihood (ML) method corrects the bias in the Reproductive number estimate occurring in method ML when the epidemic curve is not observed from the first case on (Obadia et al., 2012). The confidence limit of the next generation matrix was obtained using Markov Chain Monte Carlo.