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. 2021 Jan 19;13:489–497. doi: 10.2147/CMAR.S286866

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© 2021 Niu et al.

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Columbamine regulates migration and invasion of glioma cells. (A) SHG44 and U251 cells were treated with Columbamine (0, 20 μM, 30 μM, and 50 μM) for 24h. The migration of glioma cells was detected by performing wound healing. n=5, *P<0.05 vs 0μM group,**P<0.01 vs 0μM group. (B) The migration and invasion ability of SHG44 and U251 cells. n=5, *P<0.05 vs 0μM group,**P<0.01 vs 0μM group. (C) The proteins level of metastasis-associated E-Cadherin, N-Cadherin, MMP2, MMP7, and MMP9 in glioma cells after columbamine treatment. n=6, *P<0.05 vs 0μM group,**P<0.01 vs 0μM group.