Table 4.
Epitope conservancy analysis of S-protein epitopes of seven HCoVs.
| Sl. no | Human CoVs strain name | Common B and T-cell epitopes sequence | Epitope (peptide) length | Percent of protein sequence matches at identity ≤ 100% | Minimum identity | Maximum identity |
|---|---|---|---|---|---|---|
| 1 | SARS-CoV-2 | VRQIAPGQT | 9 | 5.26% (1/19) | 11.11% | 100.00% |
| 2 | YQAGSTPCN | 9 | 5.26% (1/19) | 11.11% | 100.00% | |
| 3 | FQPTNGVGF | 9 | 0.00% (0/19) | 22.22% | 88.89% | |
| 4 | ILPDPSKPS | 9 | 5.26% (1/19) | 11.11% | 100.00% | |
| 5 | SARS-CoV | VRQIAPGQT | 9 | 5.56% (1/18) | 22.22% | 100.00% |
| 6 | FSPDGKPCT | 9 | 5.56% (1/18) | 22.22% | 100.00% | |
| 7 | MERS-CoV | LLSGTPPQV | 9 | 5.00% (1/20) | 22.22% | 100.00% |
| 8 | YGTDTNSVC | 9 | 5.00% (1/20) | 22.22% | 100.00% | |
| 9 | LTPRSVRSV | 9 | 5.00% (1/20) | 22.22% | 100.00% | |
| 10 | YQNISTNLP | 9 | 5.00% (1/20) | 11.11% | 100.00% | |
| 11 | LGNSTGIDF | 9 | 5.00% (1/20) | 22.22% | 100.00% | |
| 12 | HCoV-OC43 | YRRKPDLPN | 9 | 0.00% (0/20) | 22.22% | 88.89% |
| 13 | FKPQPAGVF | 9 | 0.00% (0/20) | 11.11% | 77.78% | |
| 14 | FTGPYKCPQ | 9 | 0.00% (0/20) | 22.22% | 88.89% | |
| 15 | HCoV-NL63 | VKSGSPGDS | 9 | 5.00% (1/20) | 22.22% | 100.00% |
| 16 | VRPRNSSDN | 9 | 5.00% (1/20) | 22.22% | 100.00% | |
| 17 | HCoV-HKU1 | ITAYDPRSC | 9 | 5.00% (1/20) | 11.11% | 100.00% |
| 18 | YNSPSSSSS | 9 | 5.00% (1/20) | 11.11% | 100.00% | |
| 19 | YYYPEPISD | 9 | 5.00% (1/20) | 11.11% | 100.00% | |
| 20 | HCoV-229E | LPRSGSRVA | 9 | 0.00% (0/17) | 22.22% | 88.89% |