Table 1.

The role of BAF subunits in mESCs.

Subunit	Phenotypes	References
BRG1	Knockdown or knockout of Brg1 resulted in ESC differentiation and downregulation of self-renewal and pluripotency genes such as Oct4 and Sox2.	[28, 31, 32]
BAF47	Knockdown of Baf47 blocks differentiation; overexpression of Baf47 enhances differentiation; knockdown of Baf57 upregulates Cdx2 expression.	[33, 34]
BAF155	Depletion of BAF155 resulted in decreased proliferation, decreased Oct4 expression, and increased apoptosis of ESCs.	[28]
BAF250a	The self-renewal ability of mESCs decreases after knocking out BAF250a, and the differentiation of ES cells into the mesoderm and endoderm is inhibited.	[35, 36]
BAF45d	Knockout of BAF45d perturbs ESC self-renewal and impairs its differentiation to three lineages.	[30]
BAF53a	Knockdown of Baf53a reduces the expression of pluripotent genes in ESCs. Baf53a protects mESCs from differentiating into primitive endoderm; knockout of Baf53a represses cell proliferation and induces cell apoptosis.	[37, 38]
BRD9	Preserving the naive pluripotency of ESCs	[39]