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. 2021 Jan 4;49(2):1075–1093. doi: 10.1093/nar/gkaa1225

Figure 1.

Figure 1.

MD simulations on the anticodon stem-loop of wild-type and mutated tRNAIle. (A) Cloverleaf structure of human mitochondrial tRNAIle. An arrow indicated the location of the m.4295A>m1G mutation. Nucleotides at the dashed box in the anticodon stem–loop of tRNAIle were used for MD simulation. (B) The tertiary structures of the anticodon stem-loop for the wild-type (gray) and mutated (dodger blue) tRNAIle. (C) Time evolution of the root mean square deviation (RMSD) values of all backbone atoms on the anticodon stem–loop for the wild-type (WT) (black curve) and mutant (MT) (red curve) of tRNAIle. (D) RMSF curves calculated from the backbone atoms for the wild-type (black lines) and mutated (red lines) anticodon stem-loop of tRNAIle.