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Widespread ASO distribution and Malat1 RNA reduction in mouse CNS. (A) spinal cord, (B) brain, (C) cortex, (D) cerebellum, (E) hippocampus, (F) thalamus, (G) hypothalamus and (H) striatum were stained for Malat1 RNA and ASO. Staining, treatment, and the scales are indicated. All sections were counter stained with hematoxylin. Mice were treated with 300 μg Malat1 ASO or PBS. IHC, immunohistochemistry; ISH in situ hybridization; PBS, phosphate-buffered saline.
