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. 2020 Dec 24;49(2):657–673. doi: 10.1093/nar/gkaa1235

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Widespread ASO accumulation and Malat1 RNA reduction in the non-human primate (NHP) CNS. (A) Real-time RT-PCR analysis and the Malat1 ASO tissue concentration (black and blue symbols respectively) are plotted for each animal in several CNS regions. Malat1 ASO concentrations for all CNS regions for all doses were measured by LC/MS. The left Y axis is for RNA levels which are plotted as % vehicle control and the right Y axis is for ASO concentrations which are plotted as μg ASO per gram of tissue. (B) Real-time RT-PCR analysis for additional CNS regions that were too small to be sampled for ASO concentration analysis. RNA levels are plotted for each animal as % vehicle control. aCSF, artificial cerebrospinal fluid.