Figure 7.
Widespread ASO distribution and Malat1 RNA reduction in the non-human primate (NHP) CNS. (A) globus pallidus, (B) caudate, (C) putamen, (D) hippocampus, (E) lateral geniculate body, (F) cerebellum, (G) deep cerebellar nuclei, (H) trigeminal ganglion, (I) cervical, (J) thoracic and (K) lumbar dorsal root ganglia are stained for Malat1 RNA and ASO. Staining, treatment, and the scales are indicated. All sections were counter stained with hematoxylin. DRG, dorsal root ganglia. IHC, immunohistochemistry; ISH, in situ hybridization; aCSF, artificial cerebrospinal fluid.