Table 2.

Physicochemical properties of alkaloids with remarkable binding energy with acetylcholinesterase, butyrylcholinesterase, and β-site amyloid precursor protein cleaving enzyme-1

S/N	Compounds	Molecular weight	H-bond acceptor	H-bond donor	MLogP	Lipinski’s violations
S	Donepezil	379.49	4	0	3.06	0
S	Elenbecestat	437.44	8	2	1.54	0
1	Genistin	432.38	10	6	− 1.61	1
2	Naphthalen-2-yl-acetic acid, 6-hydroxy-6-methyl-cyclodecyl ester	354.48	3	1	4.02	0
3	Naringin	580.53	14	8	− 2.77	3
4	Orientin	448.38	11	8	− 2.51	2
5	Vitexin	432.38	10	7	− 2.02	1

MLOGP cctanol/water partition coefficient