The distribution of CoNeS for genes underlying inborn errors of immunity (IEI). (A) The number of genes underlying IEI, according to the mode of disease inheritance. (B) The distribution of CoNeS for autosomal genes underlying IEI, according to their dominant (AD), recessive (AR), or both dominant and recessive (AR/AD) mode of inheritance, relative to autosomal background (AB) genes. (C) The distribution of CoNeS for X-linked genes underlying IEI, relative to autosomal (AB) and X chromosome (XB) background genes.