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The distribution of CoNeS for genes underlying inborn errors of immunity (IEI), according to disease, age of onset, and penetrance. (A) The number of IEI genes underlying early-onset, highly penetrant (EOHP) and later-onset, incompletely penetrant (LOIP) IEI, according to the mode of disease inheritance. (B) The distribution of CoNeS for the IEI genes, as a function of age of onset, penetrance, and mode of inheritance.
