Table 1.

Statistical significance of differences in negative selection scores between genes underlying AD IEI and AB genes

Score	Wilcoxon-based test	Resampling-based test
evoTol	0.209	0.767
f parameter	5.16 × 10−7	5 × 10−4
LOEUF	1.29 × 10−7	<10−5
lofTool	3.25 × 10−5	2.70 × 10−3
pLI	1.59 × 10−5	<10−5
RVIS	3.29 × 10−6	2.42 × 10−2
SIS	4.48 × 10−5	7.60 × 10−3
CoNeS	1.71 × 10−9	<10−5

The P values for a one-tailed Wilcoxon test and a resampling-based test (Methods) assessing the difference between IEI AD genes and AB genes are shown.