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. 2021 Jan 6;118(3):e2001248118. doi: 10.1073/pnas.2001248118

Table 1.

Statistical significance of differences in negative selection scores between genes underlying AD IEI and AB genes

Score Wilcoxon-based test Resampling-based test
evoTol 0.209 0.767
f parameter 5.16 × 10−7 5 × 10−4
LOEUF 1.29 × 10−7 <10−5
lofTool 3.25 × 10−5 2.70 × 10−3
pLI 1.59 × 10−5 <10−5
RVIS 3.29 × 10−6 2.42 × 10−2
SIS 4.48 × 10−5 7.60 × 10−3
CoNeS 1.71 × 10−9 <10−5

The P values for a one-tailed Wilcoxon test and a resampling-based test (Methods) assessing the difference between IEI AD genes and AB genes are shown.