TABLE 2.
Total population | ||||
---|---|---|---|---|
Baseline category BMI Metabolic health status |
MHNO <25 kg/m2 0–1 risk factor |
MHO ≥25 kg/m2 0–1 risk factor |
MUNO <25 kg/m2 ≥2 risk factors |
MUO ≥25 kg/m2 ≥2 risk factors |
Total population | ||||
N (% of total) | 93,577 (29.3) | 28,557 (8.9) | 111,025 (34.8) | 86,238 (27.0) |
Number of events (%) | 1643 (1.8) | 567 (2.0) | 2644 (2.4) | 2009 (2.3) |
Crude HR (95% CI) | 1 (ref) | 1.13 (1.03–1.24) | 1.36 (1.28–1.45) | 1.32 (1.24–1.41) |
p‐value | Ref | 0.013 | <0.001 | <0.001 |
Multivariable‐adjusted HR (95% CI) a | 1 (ref) | 1.14 (1.04–1.26) | 1.19 (1.12–1.27) | 1.21 (1.13–1.29) |
Multivariable‐adjusted p‐value | Ref | 0.006 | <0.001 | <0.001 |
Men | ||||
N (% of total) | 44,194 (26.5) | 13,824 (8.3) | 60,416 (36.2) | 48,536 (29.1) |
Number of events (%) | 935 (2.1) | 314 (2.3) | 1625 (2.7) | 1262 (2.6) |
Crude HR (95% CI) | 1 (ref) | 1.08 (0.95–1.23) | 1.28 (1.18–1.38) | 1.23 (1.13–1.34) |
p‐value | Ref | 0.250 | <0.001 | <0.001 |
Multivariable‐adjusted HR (95% CI) b | 1 (ref) | 1.18 (1.04–1.34) | 1.23 (1.13–1.33) | 1.29 (1.19–1.41) |
Multivariable‐adjusted p‐value | Ref | 0.011 | <0.001 | <0.001 |
Women | ||||
N (% of total) | 49,383 (32.4) | 14,733 (9.7) | 50,609 (33.2) | 37,702 (24.7) |
Number of events (%) | 708 (1.4) | 253 (1.7) | 1019 (2.0) | 747 (2.0) |
Crude HR (95% CI) | 1 (ref) | 1.19 (1.03–1.37) | 1.40 (1.27–1.54) | 1.36 (1.23–1.51) |
p‐value | Ref | 0.019 | <0.001 | <0.001 |
Multivariable‐adjusted HR (95% CI) b | 1 (ref) | 1.14 (0.99–1.32) | 1.21 (1.09–1.33) | 1.17 (1.06–1.30) |
Multivariable‐adjusted p‐value | Ref | 0.066 | <0.001 | <0.001 |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; MHNO, metabolically healthy non‐obesity; MHO, metabolically healthy obesity; MUNO, metabolically unhealthy non‐obesity; MUO, metabolically unhealthy obesity.
Adjusted for baseline age, sex, income, smoking, alcohol drinking, and presence of IBD.
Adjusted for baseline age, income, smoking, alcohol drinking, and presence of IBD.