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. 2020 Nov 20;10(1):220–229. doi: 10.1002/cam4.3607

TABLE 2.

Risk of incident CRC according to baseline metabolic health and obesity status.

Total population

Baseline category

BMI

Metabolic health status

MHNO

<25 kg/m2

0–1 risk factor

MHO

≥25 kg/m2

0–1 risk factor

MUNO

<25 kg/m2

≥2 risk factors

MUO

≥25 kg/m2

≥2 risk factors

Total population
N (% of total) 93,577 (29.3) 28,557 (8.9) 111,025 (34.8) 86,238 (27.0)
Number of events (%) 1643 (1.8) 567 (2.0) 2644 (2.4) 2009 (2.3)
Crude HR (95% CI) 1 (ref) 1.13 (1.03–1.24) 1.36 (1.28–1.45) 1.32 (1.24–1.41)
p‐value Ref 0.013 <0.001 <0.001
Multivariable‐adjusted HR (95% CI) a 1 (ref) 1.14 (1.04–1.26) 1.19 (1.12–1.27) 1.21 (1.13–1.29)
Multivariable‐adjusted p‐value Ref 0.006 <0.001 <0.001
Men
N (% of total) 44,194 (26.5) 13,824 (8.3) 60,416 (36.2) 48,536 (29.1)
Number of events (%) 935 (2.1) 314 (2.3) 1625 (2.7) 1262 (2.6)
Crude HR (95% CI) 1 (ref) 1.08 (0.95–1.23) 1.28 (1.18–1.38) 1.23 (1.13–1.34)
p‐value Ref 0.250 <0.001 <0.001
Multivariable‐adjusted HR (95% CI) b 1 (ref) 1.18 (1.04–1.34) 1.23 (1.13–1.33) 1.29 (1.19–1.41)
Multivariable‐adjusted p‐value Ref 0.011 <0.001 <0.001
Women
N (% of total) 49,383 (32.4) 14,733 (9.7) 50,609 (33.2) 37,702 (24.7)
Number of events (%) 708 (1.4) 253 (1.7) 1019 (2.0) 747 (2.0)
Crude HR (95% CI) 1 (ref) 1.19 (1.03–1.37) 1.40 (1.27–1.54) 1.36 (1.23–1.51)
p‐value Ref 0.019 <0.001 <0.001
Multivariable‐adjusted HR (95% CI) b 1 (ref) 1.14 (0.99–1.32) 1.21 (1.09–1.33) 1.17 (1.06–1.30)
Multivariable‐adjusted p‐value Ref 0.066 <0.001 <0.001

Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; MHNO, metabolically healthy non‐obesity; MHO, metabolically healthy obesity; MUNO, metabolically unhealthy non‐obesity; MUO, metabolically unhealthy obesity.

a

Adjusted for baseline age, sex, income, smoking, alcohol drinking, and presence of IBD.

b

Adjusted for baseline age, income, smoking, alcohol drinking, and presence of IBD.