TABLE 3.
Risks of incident CRC according to the transition from metabolically healthy to unhealthy status among subjects with obesity in reference to the stable MHNO group.
| Baseline obesity status | MHNO | MHO | MUO | ||
|---|---|---|---|---|---|
| Follow‐up category | MHNO |
MHO Stable healthy |
MUO Healthy to unhealthy |
MHO Unhealthy to healthy |
MUO Stable unhealthy |
| Total population | |||||
| N (% of respective baseline category) | 56,157 (69.3) | 11,641 (47.3) | 8715 (35.3) | 9914 (7.6) | 53,073 (40.7) |
| Number of events (%) | 901 (1.60) | 179 (1.54) | 199 (2.28) | 179 (1.81) | 1246 (2.35) |
| Crude HR (95% CI) | 1 (ref) | 0.96 (0.82–1.13) | 1.42 (1.22–1.66) | 1.20 (0.95–1.31) | 1.46 (1.34–1.59) |
| p‐value | Ref | 0.609 | <0.001 | 0.169 | <0.001 |
| Multivariable‐adjusted HR (95% CI) a | 1 (ref) | 0.97 (0.83–1.14) | 1.34 (1.15–1.57) | 1.06 (0.91–1.25) | 1.29 (1.19–1.41) |
| Multivariable‐adjusted p‐value | Ref | 0.735 | <0.001 | 0.449 | <0.001 |
| Men | |||||
| N (% of respective baseline category) | 25,515 (66.9) | 5507 (72.4) | 4382 (17.8) | 5565 (13.2) | 30,522 (72.2) |
| Number of events (%) | 504 (1.98) | 99 (1.80) | 114 (2.60) | 118 (2.12) | 783 (2.57) |
| Crude HR (95% CI) | 1 (ref) | 0.92 (0.74–1.14) | 1.33 (1.09–1.63) | 1.08 (0.88–1.32) | 1.31 (1.17–1.46) |
| p‐value | Ref | 0.439 | 0.006 | 0.454 | <0.001 |
| Multivariable‐adjusted HR (95% CI) b | 1 (ref) | 1.02 (0.82–1.27) | 1.40 (1.14–1.72) | 1.18 (0.97–1.45) | 1.36 (1.21–1.52) |
| Multivariable‐adjusted p‐value | Ref | 0.836 | 0.001 | 0.105 | <0.001 |
| Women | |||||
| N (% of respective baseline category) | 30,642 (71.4) | 6.134 (48.3) | 4333 (17.6) | 4349 (13.6) | 22,551 (70.4) |
| Number of events (%) | 397 (1.30) | 80 (1.30) | 85 (1.96) | 61 (1.40) | 463 (2.05) |
| Crude HR (95% CI) | 1 (ref) | 1.00 (0.79–1.27) | 1.49 (1.18–1.88) | 1.06 (0.81–1.38) | 1.31 (1.17–1.46) |
| p‐value | Ref | 0.993 | <0.001 | 0.693 | <0.001 |
| Multivariable‐adjusted HR (95% CI) b | 1 (ref) | 0.97 (0.76–1.23) | 1.37 (1.08–1.74) | 0.98 (0.75–1.29) | 1.35 (1.17–1.56) |
| Multivariable‐adjusted p‐value | Ref | 0.791 | 0.009 | 0.903 | <0.001 |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; MHNO, metabolically healthy non‐obesity; MHO, metabolically healthy obesity; MUNO, metabolically unhealthy non‐obesity; MUO, metabolically unhealthy obesity.
a
Adjusted for baseline age, sex, income, smoking, alcohol drinking, and presence of IBD.
b
Adjusted for baseline age, income, smoking, alcohol drinking, and presence of IBD.