Table 4.
Pamiparib accumulation rate
| Parameter | Dose | n | Accumulation ratio | 95% CI |
|---|---|---|---|---|
| AUC0‐12 (h*ng/mL) | 20 mg BID | 4 | 2.05 | 1.52‐2.77 |
| AUC0‐12 (h*ng/mL) | 40 mg BID | 4 | 3.95 | 2.92‐5.34 |
| AUC0‐12 (h*ng/mL) | 60 mg BID | 5 | 3.36 | 2.56‐4.40 |
| Cmax (ng/mL) | 20 mg BID | 4 | 1.78 | 1.16‐2.75 |
| Cmax (ng/mL) | 40 mg BID | 4 | 3.19 | 2.07‐4.92 |
| Cmax (ng/mL) | 60 mg BID | 5 | 2.62 | 1.78‐3.85 |
Abbreviations: AUC, area under the plasma concentration‐time curve from time of drug administration to time (12 hours) or to the last measurable concentration; BID, twice daily; CI, confidence interval; Cmax, maximum observed plasma concentration.