Table 3.

Univariable and multivariable analysis for overall survival.

Covariate	Univariable		Multivariable
	HR (95% CI)	p‐value	HR (95% CI)	p‐value
Age	1.05 (1–1.02)	0.066	1.01 (0.99–1.02)	0.44
Sex (male)	0.89 (0.63–1.25)	0.51	1.34 (0.87–2.06)	0.19
Race (non‐Asian)	0.76 (0.5–1.15)	0.2	0.83 (0.49–1.41)	0.5
Number of metastatic sites	1.17 (1.02–1.34)	0.029
ECOG		<0.001		<0.001
0	Reference		Reference
1	1.47 (0.99–2.17)	0.055	1.17 (0.74–1.84)	0.5
2	4.03 (2.23–7.26)	<0.001	2.64 (1.37–5.07)	0.0037
3–4	6.15 (3.34–11.3)	<0.001	9.28 (4.08–21.13)	<0.001
BMI < 18.5	1.22 (0.62–2.4)	0.57	0.66 (0.25–1.77)	0.41
Baseline NRI < 97.5	1.92 (1.32–2.78)	<0.001	1.77 (1.07–2.92)	0.025
Baseline Sarcopenia	1.24 (0.9–1.72)	0.19	0.97 (0.65–1.45)	0.88
NRI change		0.059		$<$ 0.001
Nourished → Nourished	Reference		Reference
Malnourished → Nourished	1.94 (0.67–5.57)	0.22	2.45 (0.71–8.46)	0.16
Nourished → Malnourished	1.78 (0.93–3.42)	0.083	6.29 (2.53–15.65)	$<$ 0.001
Malnourished → Malnourished	2.17 (1.17–4.04)	0.014	7.11 (2.22–22.75)	$<$ 0.001
Change in SMI		0.63		0.098
Stable	Reference		Reference
Increase 10%	0.67 (0.24–1.89)	0.44	0.29 (0.08–0.97)	0.045
Decrease 10%	1.09 (0.7–1.7)	0.7	1.19 (0.66–2.16)	0.56