Figure 1.

Colon adenocarcinoma (COAD) tissues showing a lower KDM6A expression and higher DNA methylation than the corresponding normal tissues. (A) Heatmap analysis used to compare gene expression, exon expression, and DNA methylation of KDM6A by UCSC. (B) Unpairedt‐test showing downregulation of KDM6A in tumor tissues was less in READ (p = 0.0017) than in COAD (p < 0.0001). (C) Downregulation of KDM6A exon expression in tumor tissues was commonly found in READ (p < 0.0001) and COAD (p < 0.0001) (D) A higher KDM6A DNA methylation in tumor tissues in COAD (p = 0.0014) tissues and not in READ (p = 0.4499) tissues