Table 1.
Genes coding for proteins involved in the activation, transport, and metabolism of DOACs [2,3,4,5,6].
| DCI | Activation | Transport | Metabolism |
|---|---|---|---|
| Dabigatran | CES1, CES2 | ABCB1 | UGT1A9, UGT2B7, UGT2B15 |
| Rivaroxaban | - | ABCB1, ABCG2 | CYP3A4/5, CYP2J2 |
| Apixaban | - | ABCB1, ABCG2 | CYP3A4/5, CYP1A2, CYP2J2 |
| Edoxaban | - | ABCB1, SLCO1B1 | CES1, CYP3A4/5 |
| Betrixaban | ABCB1 | CYP450-independent hydolysis |
ABCB1: ATP-binding cassette isoforme B1; ABCG2: ATP-binding cassette isoforme G2; CES: carboxyesterase; CYP: Cytochrome P450; SLCO1B1: solute carrier organic anion transporter family, member 1B1; UGT: UDP-glucuronyltransferase.