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Overview of obesity-associated metabolic inflammation and insulin resistance. NLRP3 inflammasome activation as a consequence of obesity-mediated immunological and metabolic dysregulation, including changes in adipose tissue-resident immune cells, impaired adipogenesis, decreased anti-inflammatory adipokines, hypoxia, fibrosis, etc., and helped by oxidative and ER stress, leads to a glucotoxicity, lipotoxicity, and systemic insulin resistance.
