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. 2021 Jan 9;22(2):598. doi: 10.3390/ijms22020598

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunomodulatory properties of MSC are not affected upon exposure to KTS. Whole splenocytes were labeled with carboxy-fluorescein succinimidyl ester (CFSE) and cultured in the presence of CD3/CD28 stimulation beads for 72 h alone (control), or together with naïve MSC (+MSC), transduced MSC (+MSC + AdV), K2TS-treated MSC (+MSC + K2) and transduced MSC in the presence of K2TS (+MSC + AdV + K2), in different ratios, as indicated. At the end of the incubation time, the proliferation index of the populations of splenocytes positive for CD45 (A), CD19 (B), CD4 (C), and CD8 (D) was calculated. The percentage of CD4+ (E) and CD8+ (F) cells from the CD45 positive splenocytes were determined and represented. * corresponds to a p-value < 0.05, and *** for p < 0.0005, by ANOVA.