Table 2.

Sensitivity, precision/positive predictive value (PPV), and F-Score for selected variant allele frequency (VAF) and tumour depth thresholds.

VAF (%)	Tumour Depth (X)	Combined Sensitivity	Combined Precision PPV	Combined F Score
2	5	0.775700935	0.83	0.801932367
5	5	0.775700935	0.83	0.801932367
10	5	0.76076555	0.81122449	0.785185185
15	5	0.712643678	0.765432099	0.738095238
20	5	0.732283465	0.801724138	0.765432099
2	10	0.778301887	0.829145729	0.802919708
5	10	0.778301887	0.829145729	0.802919708
10	10	0.763285024	0.81025641	0.786069652
15	10	0.715116279	0.763975155	0.738738739
20	10	0.744	0.801724138	0.771784232
2	15	0.773584906	0.83248731	0.80195599
5	15	0.773584906	0.83248731	0.80195599
10	15	0.758454106	0.813471503	0.785
15	15	0.709302326	0.767295597	0.737160121
20	15	0.736	0.807017544	0.769874477
2	20	0.763033175	0.829896907	0.795061728
5	20	0.763033175	0.829896907	0.795061728
10	20	0.747572815533981	0.810526316	0.777777778
15	20	0.695906433	0.762820513	0.727828746
20	20	0.717741935	0.801801802	0.757446809
2	25	0.759615385	0.822916667	0.79
5	25	0.759615385	0.822916667	0.79
10	25	0.748768473	0.808510638	0.777493606
15	25	0.704142012	0.767741935	0.734567901
20	25	0.729508197	0.809090909	0.767241379
2	30	0.747572816	0.814814815	0.779746835
5	30	0.747572816	0.814814815	0.779746835
10	30	0.736318408	0.8	0.766839378
15	30	0.694610778	0.753246753	0.722741433
20	30	0.716666667	0.788990826	0.751091703