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S1P synthesis, degradation and interaction with HIFs. Sphingosine-1-phosphate—S1P; sphingosine kinase-1 and 2—SPHK1 and 2; S1P phosphatase—SGPP; S1P lyase—SGPL1; ethanolamine phosphate—EAP; hypoxia-inducible factors—HIFs, hypoxia response elements—HREs.
