Figure 2.

Examples of AR domain-containing proteins based on AR repeat number. AR domains can contain a wide variety of repeats, but predominately contain four to six. With each repeat, the 90° and L-shape formation becomes more prevalent resulting in a 3D revolving twist. In general, with each additional AR repeat, there is a correlation between complexity of the AR-containing protein’s biological role in cellular processes that it regulates. This may be due to the increased number in substrate binding pockets available that could be recognized by the substrate. The AR domain-containing proteins discussed in this review are highlighted in bold.